About us



The major focus of the Ryten Laboratory is the use of transcriptomic data as a functional read-out of the genome to inform our understanding of biological processes to improve human health. We work in neurogenetics, one of the most challenging disease areas, and use transcriptomic data, primarily derived from human brain or brain-relevant cell types, to build the resources required to improve the molecular understanding of complex and rare neurological diseases with a particular focus on neurodegenerative diseases.

As part of the UK DRI Cambridge, and in collaboration with important institutions, such as UCL Great Ormond Street Institute of Child Health and Queen Square Institute of Neurology (London), our on-going work covers the use of short-read, long-read and single-nucleous RNA-sequencing data to understand genetic regulation of gene expression mostly in the human brain, re-annotation of genes associated with neurological diseases and the use of transcriptomics to improve diagnostic yield. Find out more about who we are and what we do.



We are a highly collaborative team!
If you are interested in collaborating or working with us, please get in touch!